Can You Safely Mix Xanax and Heroin Together?

According to the book The Benzodiazepines: Use, Overuse, Misuse, Abuse, Xanax (alprazolam) is a benzodiazepine medication that is most often prescribed for anxiety management, particularly the anxiety that occurs as a result of having a psychiatric disorder or medical condition. It may also be used as a sleep aid, for seizure control, or as a preanesthetic.

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In some cases, the drug can be used to treat withdrawal symptoms associated with alcohol or the abuse of other benzodiazepines: however, typically long-acting benzodiazepines are used for that purpose.

Xanax was initially developed as an alternative to Valium (diazepam), which had become a significant drug of abuse. Xanax has a quicker onset of action and shorter half-life, so it was believed these qualities would make Xanax less likely to be abused.

However, sources such as the National Institute on Drug Abuse (NIDA) and the Substance Abuse and Mental Health Services Administration (SAMHSA) consistently report that Xanax is one of the most widely abused drugs in the country.

115 Americans fatally overdose daily. Don’t be a statistic. Get the help you need NOW!

115 Americans fatally overdose daily. Don’t be a statistic. Get the help you need NOW!

How Xanax and Heroin Work

The mechanism of action of Xanax is to work through the neurotransmitter GABA (gamma-Aminobutyric acid), which slows down the firing rates of the neurons in the brain and spinal cord. The U.S. Drug Enforcement Administration (DEA) lists Xanax in the Schedule IV controlled substances category.

brain on xanax and heroin

Heroin is an illicit drug that belongs to the class of opiate drugs. This substance was also developed as an alternative to another drug in the same class, morphine. However, heroin was found to be even more addictive than morphine, so it was eventually made illegal in the United States, although some countries still do allow its use.

Heroin works by attaching to the endogenous opiate receptors in the brain. Like Xanax, it slows down the functioning of the neurons in the brain and spinal cord but through this different mechanism. The DEA classifies heroin as a Schedule I controlled substance.

This means that the drug is considered to have no medical uses and cannot be prescribed. Possession of the drug is a crime, and only organizations that have the approval to possess small amounts of the drug (most often for research purposes) can have it.

Mixing Xanax and Heroin

NIDA reports that benzodiazepines often are not primary drugs of abuse, but they are instead abused along with other drugs. The most common drugs that are abused with benzodiazepines are opiate drugs such as heroin, alcohol, and other benzodiazepines. The major mechanism of action of these drugs is to suppress the functioning of the neurons in the central nervous system (CNS).

When people combine CNS depressants, they are engaging in very dangerous behavior. According to the book Neuropathology of Drug Addictions and Substance Misuse Volume 3, the effects of CNS depressants can be serious, especially when combined.

  • If very low doses are taken, individuals will feel sedation, relaxed, uninhibited, and have decreased reaction time and coordination.
  • At moderate doses, the above effects will be more significant. Users will also experience significant problems with their thinking that can include:
    • Impaired attention and concentration
    • Impaired judgment
    • Impaired ability to control inhibitions
    • Impaired emotional control
  • In addition to the above effects, at low and moderate doses, these drugs will suppress normal body functions that will result in a decrease in:
    • Breathing rate
    • Heart rate
    • Blood pressure
  • At higher doses, the above effects can become significant. The potential exists for an individual to experience a complete cessation of breathing, which can lead to significant brain damage or even death.
  • Significant effects on the brain can occur from the abuse of either Xanax or heroin, and combining these drugs increases the risk for this. Acute brain damage due to oxygen deprivation or a complete shutoff of oxygen may occur.
  • Long-term brain damage may also occur if these drugs are combined on a regular basis.
  • The major problem of combining CNS depressants is that there is an enhancement of the effects of both drugs. When they are combined, lower dosages of either drug are needed to experience detrimental effects.

The potential for a fatal overdose on either drug is significantly increased when Xanax and heroin are used in combination, even if they are used at low doses. An overdose on either drug can be potentially fatal.

Individuals who overdose on opiates can be treated with the drug Narcan (naloxone); however; Narcan is not effective to treat an overdose on benzodiazepines. Thus, an individual who has overdosed on a combination of these drugs may require a complicated treatment approach that may not be effective fast enough to counterbalance any potential dangers that may occur from too much of either of these drugs.

There are also some other concerns when central nervous system depressant drugs like heroin and Xanax are combined.

  • People who combine these drugs will experience significant impairment in judgment and their ability to inhibit their behavior. They are very likely to engage in risky behaviors that can result in serious consequences, such as:
    • Needle sharing
    • Engaging in unprotected sex or sex with multiple partners
    • Becoming the victim of a crime
    • Engaging in criminal activity
    • Being unable to monitor their use of the drugs, increasing the potential for overdose

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  • The chronic combination of these drugs will result in a significant burden on numerous organ systems, including the cardiovascular system, liver, kidneys, and respiratory system.
    • Repeatedly using central nervous system depressants can result in an increased potential to develop respiratory problems due to chronic decreased breathing rates when under the influence of these drugs.
    • Chronically combining these drugs can lead to significant damage to the excretory system (liver and/or kidneys).
    • Increased burden to the cardiovascular system can lead to significant problems over the long term, such as heartbeat irregularities, the potential to develop forms of cardiac disease, and other burdens on the cardiovascular system.
  • Both Xanax and heroin have the potential to produce physical dependence in people who chronically use them. Combining them may result in very complicated withdrawal issues over the long term.

Use or Abuse?

A combination of Xanax and heroin should not be taken under any circumstances. Individuals who combine any opiate drug and benzodiazepine are abusing these drugs, unless instructed to do so by a physician. Moreover, combining these drugs can be potentially dangerous even when they are combined in very small amounts because of the enhancement of their effects. Thus, there is no safe amount of Xanax and heroin that can be combined.

It is not safe to combine these drugs under any circumstances or in any amount. Anyone who combines Xanax and heroin is engaging in a serious form of drug abuse that could result in overdose and other long-term health issues.

Call (844) 432-0416 to hear more about the therapy options that might be available to you. Even though addiction is difficult to overcome, you don’t have to go through it on your own. Start your road to recovery today.